Analysis toolkit for evaluation of drug titration practice in acute lymphoblastic leukemia maintenance.

ABSTRACT:

Objective

During the 2-year maintenance treatment phase (MT) of acute lymphoblastic leukemia (ALL), personalized patient-specified titration of oral antimetabolite drug doses is required to ensure maximum tolerated systemic drug exposure. Drug titration is difficult to implement in practice and insufficient systemic drug exposure resulting from inadequate dose titration increases risk of ALL relapse.

Materials and methods

We developed an open-source R-based analytical toolkit, including the allMT R package and an interactive web-based R Shiny VIATAMIN application, to evaluate antimetabolite drug titration during MT.

Results

Evaluation is initiated with basic visualization analysis of drug titration, in both individual patients and patient cohorts. Observations are sup

SUBMITTER: Mungle T 

PROVIDER: S-EPMC11398893 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature