Establishing a model predicting Gleason grade group upgrading in prostate cancer.

ABSTRACT:

Background

Gleason grade group (GG) upgrading is associated with increased biochemical recurrence (BCR), local progression, and decreased cancer-specific survival (CSS) in prostate cancer (PCa). However, descriptions of the risk factors of GG upgrading are scarce. The objective of this study was to identify risk factors and establish a model to predict GG upgrading.

Methods

There were 361 patients with PCa who underwent radical prostatectomy between May 2011 and February 2022 enrolled. Univariate and multivariate logistic regression analyses were identified and nomogram further narrowed down the contributing factors in GG upgrading. The correction curve and decision curve were used to assess the model.

Results

In the overall cohort, 141 patients had GG upgrading. But

SUBMITTER: Chen J 

PROVIDER: S-EPMC11399042 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature