Methylenetetrahydrofolate reductase (MTHFR) polymorphisms in andrology-a narrative review.

ABSTRACT:

Background and objective

Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme involved in folate metabolism and one-carbon metabolism. MTHFR gene polymorphism affects enzyme activity. MTHFR gene polymorphism is closely related to many human diseases, such as cardiocerebrovascular diseases, diabetes, neural tube defects (NTDs), tumors, and so on. In the field of Andrology, MTHFR gene polymorphism may be associated with male infertility and erectile dysfunction (ED), and there is a possibility of treating male infertility and ED by supplementing with folic acid. However, its exact pathophysiologic mechanism is not fully understood. We sought to obtain a robust understanding of the interactions between MTHFR gene polymorphism, oxidative stress, DNA methylation, hyperhomocystein

SUBMITTER: Xie Z 

PROVIDER: S-EPMC11399056 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature