The innate immune regulator MyD88 dampens fibrosis during zebrafish heart regeneration.

ABSTRACT: The innate immune response is triggered rapidly after injury and its spatiotemporal dynamics are critical for regeneration; however, many questions remain about its exact role. Here we show that MyD88, a key component of the innate immune response, controls not only the inflammatory but also the fibrotic response during zebrafish cardiac regeneration. We find in cryoinjured myd88^-/- ventricles a significant reduction in neutrophil and macrophage numbers and the expansion of a collagen-rich endocardial population. Further analyses reveal compromised PI3K/AKT pathway activation in the myd88^-/- endocardium and increased myofibroblasts and scarring. Notably, endothelial-specific overexpression of myd88 reverses these neutrophil, fibrotic and scarring phenotypes. Mechanist

SUBMITTER: Goumenaki P 

PROVIDER: S-EPMC11399109 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature