Elevated body mass index is not significantly associated with reduced influenza vaccine effectiveness.

ABSTRACT: Elevated body mass index (BMI) has been linked to severe influenza illness and impaired vaccine immunogenicity, but the relationship between BMI and clinical vaccine effectiveness (VE) is less well described. This secondary analysis of data from a test-negative study of outpatients with acute respiratory illness assessed BMI and VE against medically attended, PCR-confirmed influenza over seven seasons (2011-12 through 2017-18). Vaccination status was determined from electronic medical records (EMR) and self-report; BMI was estimated from EMR-documented height and weight categorized for adults as obesity (≥ 30 kg/m²), overweight (25-29 kg/m²), or normal and for children based on standardized z-scales. Current season VE by virus type/subtype was estimated separately for

SUBMITTER: King JP 

PROVIDER: S-EPMC11399117 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature