Palmitic acid promotes miRNA release from adipocyte exosomes by activating NF-κB/ER stress.

ABSTRACT:

Objective

The release of adipose tissue-derived miRNAs is increased under conditions of obesity, but the exact molecular mechanisms involved have not been elucidated. This study investigated whether obesity-induced increases in palmitic acid (PA) content could activate the NF-κB/endoplasmic reticulum stress (ER stress) pathway and promote the expression and release of exosomal miRNAs in adipocytes.

Methods

Abdominal adipose tissue and serum samples were collected from normal weight individuals and people with obesity to clarify the correlation of serum PA content with NF-κB/ER stress and the release of exosomal miRNAs. NF-κB and ER stress were blocked in obese mice and in vitro cultured adipocytes to demonstrate the molecular mechanisms by which PA promotes the release of ex

SUBMITTER: Li M 

PROVIDER: S-EPMC11399118 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature