Dorsal CA3 overactivation mediates witnessing stress-induced recognition memory deficits in adolescent male mice.

ABSTRACT: Witnessing violent or traumatic events is common during childhood and adolescence and could cause detrimental effects such as increased risks of psychiatric disorders. This stressor could be modeled in adolescent laboratory animals using the chronic witnessing social defeat (CWSD) paradigm, but the behavioral consequences of CWSD in adolescent animals remain to be validated for cognitive, anxiety-like, and depression-like behaviors and, more importantly, the underlying neural mechanisms remain to be uncovered. In this study, we first established the CWSD model in adolescent male mice and found that CWSD impaired cognitive function and increased anxiety levels and that these behavioral deficits persisted into adulthood. Based on the dorsal-ventral functional division in hippocampus, we empl

SUBMITTER: Liu X 

PROVIDER: S-EPMC11399124 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature