Single-cell sequencing analysis of multiple myeloma heterogeneity and identification of new theranostic targets.

ABSTRACT: Multiple myeloma (MM) is a heterogeneous and incurable tumor characterized by the malignant proliferation of plasma cells. It is necessary to clarify the heterogeneity of MM and identify new theranostic targets. We constructed a single-cell transcriptome profile of 48,293 bone marrow cells from MM patients and health donors (HDs) annotated with 7 continuous B lymphocyte lineages. Through CellChat, we discovered that the communication among B lymphocyte lineages between MM and HDs was disrupted, and unique signaling molecules were observed. Through pseudotime analysis, it was found that the differences between MM and HDs were mainly reflected in plasma cells. These differences are primarily related to various biological processes involving mitochondria. Then, we identified the key subpopula

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11399131 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature