Phylogeny predicts sensitivity in aquatic animals for only a minority of chemicals.

ABSTRACT: There are substantial gaps in our empirical knowledge of the effects of chemical exposure on aquatic life that are unlikely to be filled by traditional laboratory toxicity testing alone. One possible alternative of generating new toxicity data is cross-species extrapolation (CSE), a statistical approach in which existing data are used to predict the effect of a chemical on untested species. Some CSE models use relatedness as a predictor of chemical sensitivity, but relatively little is known about how strongly shared evolutionary history influences sensitivity across all chemicals. To address this question, we conducted a survey of phylogenetic signal in the toxicity data from aquatic animal species for a large set of chemicals using a phylogeny inferred from taxonomy. Strong phylogenetic

SUBMITTER: Coleman AL 

PROVIDER: S-EPMC11399186 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature