Quantitative assessment of background parenchymal enhancement is associated with lifetime breast cancer risk in screening MRI.

ABSTRACT:

Objectives

To compare the quantitative background parenchymal enhancement (BPE) in women with different lifetime risks and BRCA mutation status of breast cancer using screening MRI.

Materials and methods

This study included screening MRI of 535 women divided into three groups based on lifetime risk: nonhigh-risk women, high-risk women without BRCA mutation, and BRCA1/2 mutation carriers. Six quantitative BPE measurements, including percent enhancement (PE) and signal enhancement ratio (SER), were calculated on DCE-MRI after segmentation of the whole breast and fibroglandular tissue (FGT). The associations between lifetime risk factors and BPE were analyzed via linear regression analysis. We adjusted for risk factors influencing BPE using propensity score matching (PSM) and c

SUBMITTER: Yan R 

PROVIDER: S-EPMC11399191 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature