Differential effects of environmental exposures on clinically relevant endophenotypes between sexes.

ABSTRACT: Sex and gender differences play a crucial role in health and disease outcomes. This study used data from the National Health and Nutrition Examination Survey to explore how environmental exposures affect health-related traits differently in males and females. We utilized a sex-stratified phenomic environment-wide association study (PheEWAS), which allowed the identification of associations across a wide range of phenotypes and environmental exposures. We examined associations between 272 environmental exposures, including smoking-related exposures such as cotinine levels and smoking habits, and 58 clinically relevant blood phenotypes, such as serum albumin and homocysteine levels. Our analysis identified 119 sex-specific associations. For example, smoking-related exposures had a stronger i

SUBMITTER: Gonzalez Zarzar T 

PROVIDER: S-EPMC11399237 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature