Cognitive performance as a behavioral phenotype associated with cocaine self-administration in female and male socially housed monkeys.

ABSTRACT: Considerable research has suggested that certain cognitive domains may contribute to cocaine misuse. However, there are gaps in the literature regarding whether cognitive performance before drug exposure predicts susceptibility to cocaine self-administration and how cognitive performance relates to future cocaine intake. Thus, the present study aimed to examine cognitive performance, as measured using automated CANTAB cognitive battery, prior to and following acquisition of cocaine self-administration under a concurrent drug vs. food choice procedure in female and male socially housed cynomolgus macaques. The cognitive battery consisted of measures of associative learning (stimulus and compound discrimination tasks), behavioral flexibility (intradimensional and extradimensional tasks), and

SUBMITTER: Allen MI 

PROVIDER: S-EPMC11399330 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature