Type 1 interferons promote Staphylococcus aureus nasal colonization by inducing phagocyte apoptosis.

ABSTRACT: Staphylococcus aureus is an important human commensal which persistently colonizes up to 30% of the human population, predominantly within the nasal cavity. The commensal lifestyle of S. aureus is complex, and the mechanisms underpinning colonization are not fully understood. S. aureus can induce an immunosuppressive environment in the nasal tissue (NT) by driving IL-10 and IL-27 to facilitate nasal colonization, indicating that S. aureus has the capacity to modulate the local immune environment for its commensal habitation. Mounting evidence suggests commensal bacteria drive type 1 interferons (IFN-I) to establish an immunosuppressive environment and whilst S. aureus can induce IFN-I during infection, its role in colonization has not yet been examined. Here, we show that S. aureus prefere

SUBMITTER: Vozza EG 

PROVIDER: S-EPMC11399434 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature