Phenotypic Changes in Phage Survivors of Multidrug-Resistant <i>Klebsiella pneumoniae</i>.

ABSTRACT: Multidrug-resistant Klebsiella pneumoniae (MDR-KP) infections have become a major global issue in the healthcare sector. Alternative viable tactics for combating bacterial infections, such as the use of bacteriophages, can be considered. One of the major challenges in phage therapy is the emergence of phage-resistant bacteria. This study isolated bacteriophages from water and soil samples against MDR-KP isolates. Susceptible bacterial hosts were exposed to phages at different concentrations and prolonged durations of time to obtain phage-resistant survivors. Phenotypic changes such as changes in growth rates, biofilm formation ability, antibiotic sensitivity patterns, and outer membrane proteins (OMPs) profiling of the survivors were studied. Our findings indicate that the phage ØKp

SUBMITTER: Ajakkala PB 

PROVIDER: S-EPMC11399516 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature