Extracorporeal cardiopulmonary resuscitation: a comparison of two experimental approaches and systematic review of experimental models.

ABSTRACT:

Background

In patients requiring extracorporeal cardiopulmonary resuscitation (ECPR), there is a need for studies to assess the potential benefits of therapeutic interventions to improve survival and reduce hypoxic-ischemic brain injuries. However, conducting human studies may be challenging. This study aimed to describe two experimental models developed in our laboratory and to conduct a systematic review of existing animal models of ECPR reported in the literature.

Results

In our experiments, pigs were subjected to 12 min (model 1) or 5 min (model 2) of untreated ventricular fibrillation, followed by 18 min (model 1) or 25 min (model 2) of conventional cardiopulmonary resuscitation. Results showed severe distributive shock, decreased brain oxygen pressure and increased int

SUBMITTER: Moreau A 

PROVIDER: S-EPMC11399547 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature