A fixel-based analysis of white matter reductions early detects Parkinson disease with mild cognitive impairment.

ABSTRACT:

Background

White matter (WM) tract alterations are early signs of cognitive impairment in Parkinson disease (PD) patients. Fixel-based analysis (FBA) has advantages over traditional diffusion tensor imaging in managing complex and crossing fibers. We used FBA to measure fiber-specific changes in patients with PD mild cognitive impairment (PD-MCI) and PD normal cognition (PD-NC).

Methods

Seventy-one patients with PD without dementia were included: 39 PD-MCI and 32 PD-NC. All underwent diffusion-weighted imaging, clinical examinations, and tests to evaluate their cognitive function globally and in five cognitive domains. FBA was used to investigate fiber-tract alterations and compare PD-MCI with PD-NC subjects. Correlations with each cognitive test were analyzed.

Results

SUBMITTER: Liao TW 

PROVIDER: S-EPMC11399627 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature