Mitophagy deficiency activates stimulator of interferon genes activation and aggravates pathogenetic cardiac remodeling.

ABSTRACT: Stimulator of interferon genes (STING) has recently been found to play a crucial role in cardiac sterile inflammation and dysfunction. The role of stimulator of interferon genes (STING) in cardiac sterile inflammation and dysfunction has been recently discovered. This study aims to examine the involvement of STING in pathological cardiac remodeling and the mechanisms that govern the activation of the STING pathway. To investigate this, transverse aortic constriction (TAC) was performed on STING knockout mice to induce pressure overload-induced cardiac remodeling. Subsequently, cardiac function, remodeling, and inflammation levels were evaluated. The STING pathway was found to be activated in the pressure overload-stressed heart and angiotensin II (Ang II)-stimulated cardiac fibroblasts. Lo

SUBMITTER: Zhou G 

PROVIDER: S-EPMC11399633 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature