Association between sleep traits and risk of colorectal cancer: a bidirectional Mendelian randomization study.

ABSTRACT:

Background

Sleep traits have been linked to diseases; particularly, their impact on cancer has received increasing attention. This study aimed to investigate whether sleep traits have a causal relationship with colorectal cancer (CRC) using two-sample Mendelian randomization (TSMR).

Methods

Genetic instrumental variables (IVs) for seven sleep traits (sleep duration, ease of getting up in the morning, morning chronotype, daytime napping, insomnia symptoms, snoring, and daytime dozing) were selected from pooled data from published genome-wide association studies (GSWSs). Two-sample multivariate Mendelian randomization (MR) analyses were conducted to assess the causal association between sleep traits and CRC. Reverse MR analyses were performed to determine the causal relationsh

SUBMITTER: He F 

PROVIDER: S-EPMC11399827 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature