YAP-based nomogram predicts poor prognosis in patients with hepatocellular carcinoma after curative surgery.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) ranks prominently in cancer-related mortality globally. Surgery remains the main therapeutic option for the treatment of HCC, but high post-operative recurrence rate makes prognostic prediction challenging. The quest for a reliable model to predict HCC recurrence continues to enhance prognosis. We aim to develop a nomogram with multiple factors to accurately estimate the risk of post-operative recurrence in patients with HCC.

Methods

A single-center retrospective study on 262 patients who underwent partial hepatectomy for HCC at the Eastern Hepatobiliary Surgery Hospital from May 2010 to April 2013 was conducted where immunohistochemistry assessed Yes-associated protein (YAP) expression in HCC. In the training cohort, a nomogram that

SUBMITTER: Zhou W 

PROVIDER: S-EPMC11399831 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature