LDHA as a predictive biomarker and its association with the infiltration of immune cells in pancreatic adenocarcinoma.

ABSTRACT:

Background

Lactate dehydrogenase A (LDHA) plays a crucial role in the final step of anaerobic glycolysis, converting L-lactate and NAD⁺ to pyruvate and nicotinamide adenine dinucleotide (NADH). Its high expression has been linked to tumorigenesis and patient survival in various human cancers. However, the full implications of LDHA's role and its correlation with clinicopathological features in pancreatic adenocarcinoma (PAAD) remain to be fully understood. This study was thus conducted to elucidate the specific functions of LDHA in PAAD, with the aim of providing more robust evidence for clinical diagnosis and treatment.

Methods

In an extensive systems analysis, we searched through numerous databases, including The Cancer Genome Atlas (TCGA) a

SUBMITTER: Zheng Q 

PROVIDER: S-EPMC11399852 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature