Intra-abdominal temperature variation during hyperthermic intraperitoneal chemotherapy evaluated via computational fluid dynamics modeling.

ABSTRACT:

Background

Hyperthermic intraperitoneal chemotherapy (HIPEC) targets intraperitoneal tumors with heated drug solutions via catheters inserted into the peritoneal space. Although studies have focused on clinical outcomes, the flow dynamics at specific intra-abdominal locations at-risk of harboring malignant cells remain poorly understood but are likely to impact the drug pharmacokinetics. Consequently, optimal protocols remain uncertain, with efficacy critically dependent on drug temperature and flow rate. This study tested the hypothesis that fluid flow dynamics at specific at-risk locations could be evaluated via a computational fluid dynamics (CFD) model of closed HIPEC in a simulated human abdominal cavity, with the goal to enable protocol optimization.

Methods

A computer

SUBMITTER: Cooney OS 

PROVIDER: S-EPMC11399869 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature