Assessing Alzheimer's disease via plasma extracellular vesicle-derived mRNA.

ABSTRACT:

Introduction

Alzheimer's disease (AD), the most prevalent neurodegenerative disorder globally, has emerged as a significant health concern. Recently it has been revealed that extracellular vesicles (EVs) play a critical role in AD pathogenesis and progression. Their stability and presence in various biofluids, such as blood, offer a minimally invasive window for monitoring AD-related changes.

Methods

We analyzed plasma EV-derived messenger RNA (mRNA) from 82 human subjects, including individuals with AD, mild cognitive impairment (MCI), and healthy controls. With next-generation sequencing, we profiled differentially expressed genes (DEGs), identifying those associated with AD.

Results

Based on DEGs identified in both the MCI and AD groups, a diagnostic model was esta

SUBMITTER: Pham LHP 

PROVIDER: S-EPMC11399882 | biostudies-literature | 2024 Jul-Sep

REPOSITORIES: biostudies-literature