Role of Mitofusin 1 in mediating reactive oxygen species in alveolar macrophages during Streptococcuspneumoniae.

ABSTRACT: Alveolar macrophages (AM) are key effectors of the immune response and are essential for host responses to S. pneumoniae. Mitochondria are highly dynamic organelles whose function aids in regulating the cell cycle, innate immunity, autophagy, redox signaling, calcium homeostasis, and mitochondrial quality control in AM. In response to cellular stress, mitochondria can engage in stress-induced mitochondrial hyperfusion (SIMH). The current study aimed to investigate the role of Mfn1 on mitochondrial control of reactive oxygen species (ROS) in AMs and the role of Mfn1 deficiency on immune responses to S. pneumoniae. Compared to Mfn1^FloxCre- controls, there were distinct histological differences in lung tissue collected from Mfn1^{Floxed; CreLysM} mice, with less injury and

SUBMITTER: Thomas D 

PROVIDER: S-EPMC11400614 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature