The proteasome activator subunit PSME1 promotes HBV replication by inhibiting the degradation of HBV core protein.

ABSTRACT: Chronic hepatitis B virus (HBV) infection is a leading cause of liver cirrhosis and hepatocellular carcinoma, representing a global health problem for which a functional cure is difficult to achieve. The HBV core protein (HBc) is essential for multiple steps in the viral life cycle. It is the building block of the nucleocapsid in which viral DNA reverse transcription occurs, and its mediation role in viral-host cell interactions is critical to HBV infection persistence. However, systematic studies targeting HBc-interacting proteins remain lacking. Here, we combined HBc with the APEX2 to systematically identify HBc-related host proteins in living cells. Using functional screening, we confirmed that proteasome activator subunit 1 (PSME1) is a potent HBV-associated host factor. PSME1 expressi

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11400625 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature