Association between glymphatic dysfunction and neurocognitive decline in patients with frontal lobe epilepsy.

ABSTRACT:

Background

The glymphatic system is essential for the maintenance of brain homeostasis. It may be impaired in patients with epilepsy, but its association with neurocognitive function remains unknown. In this study, we aimed to elucidate the association between changes in the glymphatic system and neurocognitive function in individuals diagnosed with frontal lobe epilepsy (FLE).

Methods

This retrospective case-control research engaged a group of patients with FLE and age-, sex-, and education-matched healthy volunteers. All participants were subjected to extensive neurocognitive assessments, complemented by structural and diffusion-weighted imaging. The "diffusion tensor imaging analysis along the perivascular space" (DTI-ALPS) index was computed to ascertain differences in g

SUBMITTER: Zhou K 

PROVIDER: S-EPMC11400664 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature