Post-capillary pulmonary hypertension in heart failure: impact of current definition in the PH-HF multicentre study.

ABSTRACT:

Background and aims

Based on retrospective studies, the 2022 European guidelines changed the definition of post-capillary pulmonary hypertension (pcPH) in heart failure (HF) by lowering the level of mean pulmonary artery pressure (mPAP) and pulmonary vascular resistance (PVR). However, the impact of this definition and its prognostic value has never been evaluated prospectively.

Methods

Stable left HF patients with the need for right heart catheterization were enrolled from 2010 to 2018 and prospectively followed up in this multicentre study. The impact of the successive pcPH definitions on pcPH prevalence and subgroup [i.e. isolated (IpcPH) vs. combined pcPH (CpcPH)] was evaluated. Multivariable Cox regression analysis was used to assess the prognostic value of mPAP and PVR

SUBMITTER: Fauvel C 

PROVIDER: S-EPMC11400736 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature