Extracellular vesicles for the treatment of ulcerative colitis: A systematic review and meta-analysis of animal studies.

ABSTRACT:

Background

Extracellular vesicles (EVs) are being considered as a potential therapeutic option for ulcerative colitis (UC), and numerous preclinical studies have been conducted on the use of EVs for UC.

Methods

A systematic review was conducted to compare the therapeutic effects of mammalian EVs and placebo on UC in animal models, along with a meta-analysis comparing naïve (unmodified) EVs and placebo. The search was performed in four databases (PubMed, Web of Science, Scopus, and EMBASE) up to September 13th, 2023. The primary outcomes included disease activity index (DAI), colonic mucosal damage index (CMDI), and adverse effects (PROSPERO ID: CRD42023458039).

Results

A total of 69 studies were included based on pre-determined criteria, involving 1271 animals. Of the

SUBMITTER: Li YJ 

PROVIDER: S-EPMC11400994 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature