Using in silico methods to determine optimal tapering regimens for decanoate-based long-acting injectable psychosis drugs.

ABSTRACT:

Background

Reducing the dose of psychosis drugs in a gradual hyperbolic manner may minimise withdrawal effects and risk of relapse. There is presently limited guidance on tapering decanoate-based long-acting injectable dopamine antagonists (LIDAs).

Objectives

We aimed to apply hyperbolic principles of tapering to the decanoate-based LIDAs flupentixol, zuclopenthixol and haloperidol to develop withdrawal regimens.

Design

We used in silico methodology to predict plasma drug levels and D₂ occupancy for different LIDA regimens.

Methods

Existing pharmacokinetic and receptor occupancy data from nuclear neuroimaging studies were used to power modelling. Abrupt discontinuation was examined as a potential strategy, and dose reduction was modelled with pre-def

SUBMITTER: O'Neill JR 

PROVIDER: S-EPMC11401015 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature