HER4 is a high-affinity dimerization partner for all EGFR/HER/ErbB family proteins.

ABSTRACT: Human epidermal growth factor receptors (HER)-also known as EGFR or ErbB receptors-are a subfamily of receptor tyrosine kinases (RTKs) that play crucial roles in cell growth, division, and differentiation. HER4 (ErbB4) is the least studied member of this family, partly because its expression is lower in later stages of development. Recent work has suggested that HER4 can play a role in metastasis by regulating cell migration and invasiveness; however, unlike EGFR and HER2, the precise role that HER4 plays in tumorigenesis is still unresolved. Early work on HER family proteins suggested that there are direct interactions between the four members, but to date, there has been no single study of all four receptors in the same cell line with the same biophysical method. Here, we quantitatively

SUBMITTER: Singh PK 

PROVIDER: S-EPMC11401057 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature