SMTRI: A deep learning-based web service for predicting small molecules that target miRNA-mRNA interactions.

ABSTRACT: Mature microRNAs (miRNAs) are short, single-stranded RNAs that bind to target mRNAs and induce translational repression and gene silencing. Many miRNAs discovered in animals have been implicated in diseases and have recently been pursued as therapeutic targets. However, conventional pharmacological screening for candidate small-molecule drugs can be time-consuming and labor-intensive. Therefore, developing a computational program to assist mature miRNA-targeted drug discovery in silico is desirable. Our previous work (https://doi.org/10.1002/advs.201903451) revealed that the unique functional loops formed during Argonaute-mediated miRNA-mRNA interactions have stable structural characteristics and may serve as potential targets for small-molecule drug discovery. Developing drugs spec

SUBMITTER: Xiao H 

PROVIDER: S-EPMC11401195 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature