T cell factor 1 (TCF-1) defines T cell differentiation in colorectal cancer.

ABSTRACT: The presence of precursor to exhausted (T_pex) CD8⁺ T cells is important to maintain robust immunity following treatment with immune checkpoint inhibition (ICI). Impressive responses to ICI are emerging in patients with stage II-III mismatch repair (MMR)-deficient (dMMR) colorectal cancer (CRC). We found 64% of dMMR and 15% of mismatch repair-proficient (pMMR) stage III CRCs had a high frequency of tumor infiltrating lymphocytes (TIL-hi). Furthermore, expression of TCF-1 (Tcf7) by CD8⁺ T cells predicted improved patient prognosis and T_pex cells (CD3⁺CD8⁺TCF-1⁺PD-1⁺) were abundant within lymphoid aggregates of stage III CRCs. In contrast, CD3⁺CD8⁺TCF-1^-PD-1⁺

SUBMITTER: Tran K 

PROVIDER: S-EPMC11401206 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature