In vivo SPECT imaging of Tc-99m radiolabeled exosomes from human umbilical-cord derived mesenchymal stem cells in small animals.

ABSTRACT: Extracellular vesicles derived from human umbilical cord-derived mesenchymal stem cells (UCMSC-EVs) have been postulated to have therapeutic potential for various diseases. However, the biodistribution and pharmacokinetics of these vesicles are still unclear. For a better understanding of the in vivo properties of UCMSC-EVs, in the present study, these vesicles were first radiolabeled with Technetium-99m (^99mTc-UCMSC-EVs) and evaluated using in vivo single photon emission computed tomography (SPECT) imaging and biodistribution experiments. SPECT images demonstrated that the liver and spleen tissues mainly took up the ^99mTc-UCMSC-EVs. The biodistribution study observed slight uptake in the thyroid and stomach, indicating that ^99mTc-UCMSC-EVs was stable at 24

SUBMITTER: Chung YH 

PROVIDER: S-EPMC11401219 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature