Role of interatrial block in modulating cryptogenic stroke risk in patients with patent foramen ovale: a retrospective study.

ABSTRACT:

Background

The patent foramen ovale (PFO) and interatrial block (IAB) are associated with cryptogenic stroke (CS). However, the role of the interaction between PFO and IAB in CS remains unclear.

Methods

This case-control study enrolled 256 patients with CS and 156 individuals without a history of stroke or transient ischemic attack. IAB was defined as P wave duration > 120 ms. PFO was evaluated by contrast transesophageal echocardiography, and classified as no-PFO, low-risk PFO and high-risk PFO. Multiplicative and additive interaction analysis were used to assess the interaction between PFO and IAB in CS.

Results

Multiplicative interaction analysis unveiled a significant interaction between IAB and low-risk PFO in CS (OR for interaction = 3.653, 95% CI, 1.115-12.506;

SUBMITTER: Du Y 

PROVIDER: S-EPMC11401249 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature