Programming Bordetella pertussis lipid A to promote adjuvanticity.

ABSTRACT:

Background

Bordetella pertussis is the causative agent of whooping cough or pertussis. Although both acellular (aP) and whole-cell pertussis (wP) vaccines protect against disease, the wP vaccine, which is highly reactogenic, is better at preventing colonization and transmission. Reactogenicity is mainly attributed to the lipid A moiety of B. pertussis lipooligosaccharide (LOS). Within LOS, lipid A acts as a hydrophobic anchor, engaging with TLR4-MD2 on host immune cells to initiate both MyD88-dependent and TRIF-dependent pathways, thereby influencing adaptive immune responses. Lipid A variants, such as monophosphoryl lipid A (MPLA) can also act as adjuvants. Adjuvants may overcome the shortcomings of aP vaccines.

Results

This work used lipid A modifying enzymes from other ba

SUBMITTER: Fathy Mohamed Y 

PROVIDER: S-EPMC11401268 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature