Mitochondrial transcriptome of Candida albicans in flagranti - direct RNA sequencing reveals a new layer of information.

ABSTRACT:

Background

Organellar transcriptomes are relatively under-studied systems, with data related to full-length transcripts and posttranscriptional modifications remaining sparse. Direct RNA sequencing presents the possibility of accessing a previously unavailable layer of information pertaining to transcriptomic data, as well as circumventing the biases introduced by second-generation RNA-seq platforms. Direct long-read ONT sequencing allows for the isoform analysis of full-length transcripts and the detection of posttranscriptional modifications. However, there are still relatively few projects employing this method specifically for studying organellar transcriptomes.

Results

Candida albicans is a promising model for investigating nucleo-mitochondrial interactions. This work c

SUBMITTER: Piatkowski J 

PROVIDER: S-EPMC11401289 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature