Recombinant ferritin-based nanoparticles as neoantigen carriers significantly inhibit tumor growth and metastasis.

ABSTRACT:

Background

Tumor neoantigen peptide-based vaccines, systemic immunotherapies that enhance antitumor immunity by activating and expanding antigen-specific T cells, have achieved remarkable results in the treatment of a variety of solid tumors. However, how to effectively deliver neoantigens to induce robust antitumor immune responses remains a major obstacle.

Results

Here, we developed a safe and effective neoantigen peptide delivery system (neoantigen-ferritin nanoparticles, neoantigen-FNs) that successfully achieved effective lymph node targeting and induced robust antitumor immune responses. The genetically engineered self-assembled particles neoantigen-FNs with a size of 12 nm were obtained by fusing a neoantigen with optimized ferritin, which rapidly drainage to and cont

SUBMITTER: Zheng W 

PROVIDER: S-EPMC11401311 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature