Maternal gut Bifidobacterium breve modifies fetal brain metabolism in germ-free mice.

ABSTRACT:

Background

Recent advances have significantly expanded our understanding of the gut microbiome's influence on host physiology and metabolism. However, the specific role of certain microorganisms in gestational health and fetal development remains underexplored.

Objective

This study investigates the impact of Bifidobacterium breve UCC2003 on fetal brain metabolism when colonized in the maternal gut during pregnancy.

Methods

Germ-free pregnant mice were colonized with or without B. breve UCC2003 during pregnancy. The metabolic profiles of fetal brains were analyzed, focusing on the presence of key metabolites and the expression of critical metabolic and cellular pathways.

Results

Maternal colonization with B. breve resulted in significant metabolic changes in the

SUBMITTER: Lopez-Tello J 

PROVIDER: S-EPMC11401360 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature