Differentially expressed extracellular matrix genes functionally separate ameloblastoma from odontogenic keratocyst.

ABSTRACT:

Background

Ameloblastoma and odontogenic keratocyst (OKC) are odontogenic tumors that develop from remnants of odontogenic epithelium. Both display locally invasive growth characteristics and high predilection for recurrence after surgical removal. Most ameloblastomas harbor BRAFV600E mutation while OKCs are associated with PATCH1 gene mutation but distinctive indicators of ameloblastoma growth characteristics relative to OKC are still unclear. The aim of this study was to assess hub genes that underlie ameloblastoma growth characteristics using bioinformatic analysis, ameloblastoma samples and mouse xenografts of human epithelial-derived ameloblastoma cells.

Methods

RNA expression profiles were extracted from GSE186489 gene expression dataset acquired from Gene Expression O

SUBMITTER: Jeyaraman P 

PROVIDER: S-EPMC11401384 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature