Deep learning approaches for non-coding genetic variant effect prediction: current progress and future prospects.

ABSTRACT: Recent advancements in high-throughput sequencing technologies have significantly enhanced our ability to unravel the intricacies of gene regulatory processes. A critical challenge in this endeavor is the identification of variant effects, a key factor in comprehending the mechanisms underlying gene regulation. Non-coding variants, constituting over 90% of all variants, have garnered increasing attention in recent years. The exploration of gene variant impacts and regulatory mechanisms has spurred the development of various deep learning approaches, providing new insights into the global regulatory landscape through the analysis of extensive genetic data. Here, we provide a comprehensive overview of the development of the non-coding variants models based on bulk and single-cell sequencing

SUBMITTER: Wang X 

PROVIDER: S-EPMC11401448 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature