Baicalein suppresses Coxsackievirus B3 replication by inhibiting caspase-1 and viral protease 2A.

ABSTRACT: Myocarditis is an inflammatory disease of the cardiac muscle and one of the primary causes of dilated cardiomyopathy. Group B coxsackievirus (CVB) is one of the leading causative pathogens of viral myocarditis, which primarily affects children and young adults. Due to the lack of vaccines, the development of antiviral medicines is crucial to controlling CVB infection and the progression of myocarditis. In this study, we investigated the antiviral effect of baicalein, a flavonoid extracted from Scutellaria baicaleinsis. Our results demonstrated that baicalein treatment significantly reduced cytopathic effect and increased cell viability in CVB3-infected cells. In addition, significant reductions in viral protein 3D, viral RNA, and viral particles were observed in CVB3-infected cells treated

SUBMITTER: Dong Y 

PROVIDER: S-EPMC11401470 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature