Individual virome analysis reveals the general co-infection of mammal-associated viruses with SARS-related coronaviruses in bats.

ABSTRACT: Bats are the natural reservoir hosts for SARS-related coronavirus (SARSr-CoV) and other highly pathogenic microorganisms. Therefore, it is conceivable that an individual bat may harbor multiple microbes. However, there is limited knowledge on the overall co-circulation of microorganisms in bats. Here, we conducted a 16-year monitoring of bat viruses in south and central China and identified 238 SARSr-CoV positive samples across nine bat species from ten provinces or administrative districts. Among these, 76 individual samples were selected for further metagenomics analysis. We found a complex microenvironment characterized by the general co-circulation of microbes from two different sources: mammal-associated viruses or environment-associated microbes. The later includes commensal bacteria

SUBMITTER: Si HR 

PROVIDER: S-EPMC11401474 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature