Lower Incidence of HCC and Other Major Adverse Liver Outcomes in People Living With HIV and Chronic Liver Disease.

ABSTRACT:

Background and aims

People living with human immunodeficiency virus (HIV) (PLWH) show a high incidence of chronic liver disease (CLD). However, whether HIV is associated with major adverse liver outcomes (MALO) in patients with underlying CLD remains to be determined.

Methods

In this population-based cohort study, data were retrieved from the Swedish National Patient Register to identify PLWH and CLD (n = 2375) or CLD without HIV (n = 144,346) between 1997 and 2020. The cumulative incidence of MALO was calculated while accounting for competing risks (non-MALO death). Incidence rates per 1000 person-years were compared between the exposure groups (HIV vs no HIV) with Cox regression to estimate adjusted hazard ratios (HRs) and their 95% confidence intervals (CIs).

Results</

SUBMITTER: Michel M 

PROVIDER: S-EPMC11401543 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature