Network excitability of stimulation-induced spectral responses helps localize the seizure onset zone.

ABSTRACT:

Objective

While evoked potentials elicited by single pulse electrical stimulation (SPES) may assist seizure onset zone (SOZ) localization during intracranial EEG (iEEG) monitoring, induced high frequency activity has also shown promising utility. We aimed to predict SOZ sites using induced cortico-cortical spectral responses (CCSRs) as an index of excitability within epileptogenic networks.

Methods

SPES was conducted in 27 epilepsy patients undergoing iEEG monitoring and CCSRs were quantified by significant early (10-200 ms) increases in power from 10 to 250 Hz. Using response power as CCSR network connection strengths, graph centrality measures (metrics quantifying each site's influence within the network) were used to predict whether sites were within the SOZ.

Results</

SUBMITTER: Hays MA 

PROVIDER: S-EPMC11401764 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature