Early experience with targeted and combination biopsies in prostate cancer work-up in Denmark from 2012 to 2016.

ABSTRACT:

Purpose

To investigate the early implementation of combined systematic and targeted (cBx) primary biopsy in prostate cancer diagnosis and define the concordance in Gleason grading (GG) of different biopsy techniques with radical prostatectomy (RP) pathology.

Methods

This population-based analysis includes data on all men in Denmark who underwent primary cBx or standalone systematic (sBx) prostate biopsy between 2012 and 2016. Biopsy results were compared to RP pathology if performed within a year. Concordance measurement was estimated using Cohen's Kappa, and the cumulative incidence of cancer-specific death was estimated at 6 years with the Aalen-Johansen estimator.

Results

Concordance between biopsy and RP pathology was 0.53 (95CI: 0.43-0.63), 0.38 (95CI: 0.29-0.48)

SUBMITTER: Blak AA 

PROVIDER: S-EPMC11401785 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature