Biodegradable oxygen-evolving metalloantibiotics for spatiotemporal sono-metalloimmunotherapy against orthopaedic biofilm infections.

ABSTRACT: Pathogen-host competition for manganese and intricate immunostimulatory pathways severely attenuates the efficacy of antibacterial immunotherapy against biofilm infections associated with orthopaedic implants. Herein, we introduce a spatiotemporal sono-metalloimmunotherapy (SMIT) strategy aimed at efficient biofilm ablation by custom design of ingenious biomimetic metal-organic framework (PCN-224)-coated MnO₂-hydrangea nanoparticles (MnPM) as a metalloantibiotic. Upon reaching the acidic H₂O₂-enriched biofilm microenvironment, MnPM can convert abundant H₂O₂ into oxygen, which is conducive to significantly enhancing the efficacy of ultrasound (US)-triggered sonodynamic therapy (SDT), thereby exposing bacteria-associated antigens (BAAs).

SUBMITTER: Su Z 

PROVIDER: S-EPMC11401848 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature