Uncovering naringin's anticancer mechanisms in glioblastoma via molecular docking and network pharmacology approaches.

ABSTRACT: Naringin, a flavonoid, exhibits diverse therapeutic properties and has been proven to exert cytotoxic effects on cancer cells. Nevertheless, the precise mechanism of naringin maintaining its cytotoxic effect on glioblastoma (GBM) remains unknown. Thus, the current study aimed to establish a plausible cellular mechanism for Naringin's inhibition of GBM. We employed various system biology techniques to forecast the primary targets, including gene ontology and cluster analysis, KEGG enrichment pathway estimation, molecular docking, MD (molecular dynamic) simulation and MMPBSA analysis. Glioblastoma target sequences were obtained via DisGeNet and Therapeutic Target Prediction, aligned with naringin targets, and analyzed for gene enrichment and ontology. Gene enrichment analysis identified the

SUBMITTER: Tharamelveliyil Rajendran A 

PROVIDER: S-EPMC11401857 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature