Metformin increases gut multidrug resistance genes in type 2 diabetes, potentially linked to Escherichia coli.

ABSTRACT: Metformin is the most commonly prescribed medication for treating type 2 diabetes (T2D). It is known that metformin can alter the gut microbiome, which influences the effectiveness of metformin treatment. We posited that if the gut microbiome, a reservoir of the resistome, is altered, then the resistome should change as well. To test this hypothesis, we reanalyzed microbiome data generated by Wu et al. (Nat Med 23(7):850-858, 2017), identifying antibiotic resistance genes (ARGs) and bacterial species. Through read-based analysis, we observed that the abundance of ARGs indeed changed in many samples treated with metformin. Moreover, the altered pattern was sufficiently heterogeneous across individual samples to allow subcategorization. We also found a strong correlation between the abundanc

SUBMITTER: Kim HB 

PROVIDER: S-EPMC11401871 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature