Integrating metagenomics with metabolomics for gut microbiota and metabolites profiling in acute pancreatitis.

ABSTRACT: Acute pancreatitis (AP) is an inflammatory disease of the pancreas. Despite of a steadily increasing in morbidity and mortality, there is still no effective therapy. Gut microbial dysbiosis and its derived-metabolites disorder have been shown to play an important role in the development of AP, however, little is known regarding the crosstalk between gut microbiota and metabolites. In this study, we assessed the alterations in gut microbiota and metabolites by constructing three AP mouse models by means of metagenomic and metabolomic sequencing, and further clarified their relationship by correlation analysis. The results revealed that each model exhibited unique flora and metabolite profiles. KEGG analysis showed that the differential flora and metabolite-enriched pathway functions were co

SUBMITTER: Jia Y 

PROVIDER: S-EPMC11401878 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature