Effect of aortic valve replacement on myocardial perfusion and exercise capacity in patients with severe aortic stenosis.

ABSTRACT: Aortic valve replacement (AVR) leads to reverse cardiac remodeling in patients with aortic stenosis (AS). The aim of this secondary pooled analysis was to assess the degree and determinants of changes in myocardial perfusion post AVR, and its link with exercise capacity, in patients with severe AS. A total of 68 patients underwent same-day echocardiography and cardiac magnetic resonance imaging with adenosine stress pre and 6-12 months post-AVR. Of these, 50 had matched perfusion data available (age 67 ± 8 years, 86% male, aortic valve peak velocity 4.38 ± 0.63 m/s, aortic valve area index 0.45 ± 0.13cm²/m²). A subgroup of 34 patients underwent a symptom-limited cardiopulmonary exercise test (CPET) to assess maximal exercise capacity (peak VO₂). Baseline an

SUBMITTER: Aslam S 

PROVIDER: S-EPMC11401907 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature