Enhancer-promoter hubs organize transcriptional networks promoting oncogenesis and drug resistance.

ABSTRACT: Recent advances in high-resolution mapping of spatial interactions among regulatory elements support the existence of complex topological assemblies of enhancers and promoters known as enhancer-promoter hubs or cliques. Yet, organization principles of these multi-interacting enhancer-promoter hubs and their potential role in regulating gene expression in cancer remain unclear. Here, we systematically identify enhancer-promoter hubs in breast cancer, lymphoma, and leukemia. We find that highly interacting enhancer-promoter hubs form at key oncogenes and lineage-associated transcription factors potentially promoting oncogenesis of these diverse cancer types. Genomic and optical mapping of interactions among enhancer and promoter elements further show that topological alterations in hubs coin

SUBMITTER: Perlman BS 

PROVIDER: S-EPMC11401928 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature